Historically, I have been rather less than sanguine about wonder drugs for weight loss, with I think quite good reason. The most promising of them to come along in years, rimonabant, was encumbered by the grisly proclivity to propagate suicide. Such is the primacy of the law of unintended consequences when we muck around with neurobiology.
Of course, we may choose to muck around less forcefully. The result of that tends to be vexing but less appalling side effects, at the cost of less therapeutic effect. So we might brand the enterprise a "damned if you do, damned if you don't" affair. And we might not be surprised that efforts to tre...
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