Uncovering clues to the genetic cause of schizophrenia

May 29, 2014 5:51 AM

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Uncovering clues to the genetic cause of schizophrenia

The overall number and nature of mutations—rather than the presence of any single mutation—influences an individual's risk of developing schizophrenia, as well as its severity, according to a discovery by Columbia University Medical Center researchers published in the latest issue of Neuron. The findings could have important implications for the early detection and treatment of schizophrenia.

Maria Karayiorgou, MD, professor of psychiatry and Joseph Gogos, MD, PhD, professor of physiology and cellular biophysics and of neuroscience, and their team sequenced the "exome"—the region of the human genome that codes for proteins—of 231 schizophrenia patients and their unaffected parents. Using...

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