Tests suggest limits to Vertex’s cystic fibrosis treatment

July 23, 2014 10:18 PM

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Tests suggest limits to Vertex’s cystic fibrosis treatment

Investors and patients were exuberant last month when Vertex Pharmaceuticals released results from clinical trials showing that cystic fibrosis patients’ lung function improved on an experimental two-drug regimen. But on Wednesday, two independent teams of scientists published studies showing that the medications interfere with each other, at least when they are administered to human cells in a laboratory dish.

The studies published in the journal Science Translational Medicine raise fundamental questions about how the drugs work in patients and also suggest that a different strategy might be more effective. Questions about the mechanism of the medicine might be largely academic if the benefits to patients...

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