Survival Benefit Found After Long-Term Resynchronization Therapy

March 30, 2014 3:30 PM

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MADIT-CRT was an influential trial that showed a reduction in heart failure complications — but not mortality — when cardiac resynchronization therapy (CRT) was added to an implantable defibrillator in patients with mild heart failure who also had left bundle-branch block (LBBB). Patients in the trial were followed for 2.4 years, raising questions about the long-term effects of CRT. Now, a second look at 854 patients who participated in a follow-up study, presented at the American College of Cardiology and published in the New England Journal of Medicine, suggests that over the long term, CRT may save lives in this population. MADIT-CRT was sponsored by Boston Scientific.

Overall, there was a highly significant 41% reduction in death (P=0.001) associated with CRT therapy in the large subgroup of patients with LBBB. The mortality rate was different after 1 year and remained significant throughout follow-up. At 7 years, the mortality rate was 29% in the control group v...

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