The Science Behind Anti-Depressants May Be Completely 'Backwards'

February 28, 2015 4:30 PM

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The Science Behind Anti-Depressants May Be Completely 'Backwards'

Andrews surveyed 50 years' worth of research supporting the serotonin theory of depression, which suggests that the disease is caused by low levels of the "happiness" neurotransmitter, serotonin.

But Andrews argues that depression may actually be caused by elevated levels of serotonin. And this fundamental misunderstanding may be responsible for inappropriate treatment: The most common form of antidepressants are selective serotonin re-uptake inhibitors (SSRIs), which operate by targeting se...

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