Rethinking Serotonin's Role in Clinical Depression

September 9, 2014 8:13 PM

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There's no denying that depression is a form of mental-health epidemic in America. An estimated 17.5 million Americans suffer from some form of depression, with approximately 9.2 million of those cases classified as major or clinical depression. But what is depression exactly? What causes it? And, more importantly, how do we fix it?

Since the 1950s, clinical depression has been thought to be caused by a chemical imbalance in the brain, specifically an imbalance of the neurotransmitter serotonin. When selective serotonin-reuptake inhibitors, or SSRIs, like Prozac, Zoloft, and Paxil, hit the market, they were wildly popular. They...

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