Proteins RhoA and ROCK1 Increase Risk of Invasive, Mobile Breast Cancer Cells

December 29, 2013 8:25 AM

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Biologists from the Johns Hopkins University have discovered a bit of shocking news. Low levels of oxygen present in many breast cancer tumors may transform cancerous cells from being rigid and stationary to mobile and invasive.

"High levels of RhoA and ROCK1 were known to worsen outcomes for breast cancer patients by endowing cancer cells with the ability to move, but the trigger for their production was a mystery," Gregg Semenza, M.D., Ph.D., the C. Michael Armstrong Professor of Medicine at the Johns Hopkins University S...

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