Old COX-2 Inhibitors Tied to Stroke Mortality

November 6, 2014 4:44 PM

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New use of nonsteroidal anti-inflammatory drugs of the first generation that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, such as diclofenac and etodolac, was associated with increased 30-day mortality following ischemic stroke in a Danish database analysis.

Compared with patients who were not taking NSAIDs other than aspirin, those who had started on old-line COX-2 inhibitors within 60 days of admission for ischemic stroke showed a 42% increase in multivariable-adjusted risk for 30-day mortality (hazard ratio 1.42, 95% CI 1.14-1.78), according to Morte...

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