Mixed Results for Thrombolysis in Pulmonary Embolism

June 17, 2014 11:19 PM

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A new meta-analysis published in JAMA analyzed data from 16 randomized trials including 2115 patients. Overall, there was a significant, 47% reduction in mortality with thrombolysis relative to standard anticoagulation, but this was accompanied by significant increases in major bleeding, including intracranial hemorrhage. The increased risk in bleeding was significant only in patients over 65 years of age.

A similar pattern was observed in the large subgroup (1775 patients) deemed to be at intermediate risk.

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