Longest-lasting cardiology guidelines built on findings of randomized controlled trials | Science Codex

May 27, 2014 9:27 PM

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Longest-lasting cardiology guidelines built on findings of randomized controlled trials | Science Codex

PHILADELPHIA –Clinical practice guideline recommendations related to screening and treatment can change markedly over time as new evidence about best practices and clinical outcomes of various treatments emerges. In a first-of-its-kind study, Penn Medicine researchers examined high-level recommendations published by the American College of Cardiology (ACC) and the American Heart Association (AHA) between 1998 and 2007 and found that recommendations which were supported by multiple randomized controlled trials were the most "durable" and least likely to change over time. Their work will be published in JAMA.

A Penn research team led by Mark D. Neuman, MD, MSc, assistant professor of Anesthesiology and Critical Care and Senior Fellow in the Leonard David Institute of Health Economics, analyzed changes over time in over 600 Class I ACC/AHA recommendations, each of which recommended strongly in favor of a ...

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