A key to aortic valve disease prevention: Lowering cholesterol early

October 27, 2014 2:31 PM

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Montreal, Sunday 26, 2014 – An international research team led by the Research Institute of the McGill University Health Centre (RI-MUHC) and Lund University has provided new evidence that aortic valve disease may be preventable. Their findings show that so-called "bad" cholesterol or low-density lipoprotein-cholesterol (LDL-C) is a cause of aortic valve disease – a serious heart condition that affects around five million people in North America and is the most common cause for valve replacement. The study, published in the Journal of the American Medical Association (JAMA) and presented at the Canadian Cardiovascular Congress in Vancouver, could have major implications in the prevention of heart valve disease, a condition that currently has no known medical therapy.

"Many people have elevations in LDL-C, normally putting them at risk for heart attacks and strokes," says senior author and RI-MUHC researcher Dr. George Thanassoulis, who is also the MUHC Director of Preventive and Genomic Cardiology and an Assistant Professor in the Faculty of Medicine at McGill U...

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