"After 7 episodes of 'Fashion Police,' I discovered that my style does not fit with the creative direction of the show and now it's time to move on," Griffin tweeted.
"I wish E! and the E! team only the best," she added. "I hope to continue to make you all laugh performing live or on television where I can be smart, irreverent, unrepentant and unafraid in an observational way that is candid, honest and justified."