Hope For Successful Alzheimer's Drug Comes After Compound Reverses The Disease In Mouse Models

May 21, 2014 3:33 PM

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Hope For Successful Alzheimer's Drug Comes After Compound Reverses The Disease In Mouse Models

Amyloid beta protein form plaques in the brain causing Alzheimer's disease: image via alz.orgResearchers at Saint Louis University have successfully reduced the symptoms of Alzheimer's in mice genetically engineered to have Alzheimer's disease (AD). The specific molecular compound that was used in the study, antisense oligonucleotide (OL-1), attacked the most widely-studied cause of AD, the accumulation of amyloid beta protein in the brain.

The over-expression of amyloid beta protein is responsibe for the formation of plaque in the brain. OL-1 was successful in blocking the translation of RNA into amyloid beta protein by decreasing the over-expression of the amyloid beta protein precursor. It thereby normalized the amount of amyloid b...

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