Exposure to dim light at night may make breast cancers resistant to tamoxifen

July 25, 2014 4:33 AM

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PHILADELPHIA — For rats bearing human breast tumors, exposure to dim light at night made the tumors resistant to the breast cancer drug tamoxifen, according to data published in Cancer Research, a journal of the American Association for Cancer Research. The negative effects of dim light exposure on tamoxifen treatment were overcome by giving rats a melatonin supplement during the night.

"Resistance to tamoxifen is a growing problem among patients with hormone receptor-positive breast cancer," said Steven M. Hill, PhD, professor of structural and cellular biology and the Edmond and Lily Safra chair for breast cancer research at Tulane University School of Medicine in New Orleans. "O...

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