How Disappointment Works In The Brain

September 29, 2014 1:54 PM

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That feeling of "oh, bummer," is linked with a rather uncommon type of brain signaling, new research shows. The finding could lead to a new class of drugs to treat depression, researchers say.

That downer feeling involves the finely tuned, simultaneous firing of two different neurotransmitters in the brain. It is the ratio of the two neurotransmitters — one enhancing and one dampening positive feelings — that determines where on the disappointment spectrum you'll fall, from "oh well" to "...

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