Dabigatran Carries Higher Risk of Major Bleeds, Lower Risk of Intracranial Hemorrhage

November 5, 2014 10:05 PM

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Dabigatran is associated with a higher risk of major bleeding and gastrointestinal (GI) hemorrhage compared with warfarin in Medicare beneficiaries with nonvalvular atrial fibrillation (A-fib), a finding consistent across high-risk subgroups, according to a study published online November 3, 2014, ahead of print in JAMA Internal Medicine. The risk of intracranial hemorrhage, however, is lower with dabigatran.

“Before more evidence is available, dabigatran should be prescribed with caution in high-risk patients,” Yuting Zhang, PhD, of the University of Pittsburgh (Pittsburgh, PA), and colleagues write. “Our study also indicates the importance of comparing the safety profiles of newer and traditional drugs...

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