Clinical trial shows drug combination may be highly effective in recurrent ovarian cancer

June 3, 2014 4:10 PM

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Clinical trial shows drug combination may be highly effective in recurrent ovarian cancer

Patients, whose median age was 58, were enrolled from October 2011 to June 2013. As of March 2014, median progression-free survival was 9.2 months for olaparib and 16.7 months for the combination therapy, which is a significant advantage. The overall rate of toxicity was higher for patients on the combination therapy. Fatigue, diarrhea, and hypertension were the most common toxic effects, all of which were manageable.

"Of particular note is the fact that both drugs used in this trial are in pill form," said Percy Ivy, M.D., associate chief of NCI's Investigational Drug Branch. "Therefore, this therapy could be used anywhere in the world where patients can be monitored for dehydration due to diarrhea side-effects ...

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