Causal Link for LDL-C, Aortic Valve Disease

October 27, 2014 5:00 PM

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MONDAY, Oct. 27, 2014 (HealthDay News) -- Genetic predisposition to low-density lipoprotein cholesterol (LDL-C) is associated with aortic valve disease, according to a study published online Oct. 26 in the Journal of the American Medical Association. The research was published to coincide with the annual Canadian Cardiovascular Congress, held from Oct. 25 to 28 in Vancouver.

J. Gustav Smith, MD, from Lund University in Sweden, and colleagues used a Mendelian randomization study design to examine whether weighted genetic risk scores (GRSs) identified in genome-wide association studies are consistent with a link between LDL-C, high-density lipoprotein cholesterol (HDL-C),...

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