Garner played Sydney Bristow, a spy for the CIA on "Alias." Meanwhile, her real-life beau Michael Vartan played her on-screen beau Michael Vaughn, another double agent for the CIA. The two eventually split. Status: Over. Garner has since married actor Ben Affleck and has two daughters -- Violet and Seraphina -- and another on the way.
Cuoco and Galecki, who play neighbors Penny and Leonard on the hit CBS sitcom "The Big Bang Theory," kept their romance a secret for two years. It was only after the two broke up that Cuoco went public with it. Status: Over -- but still friends.